Anti XRCC3 Clone XRCC3 10F1/6 Profile

Antigen: XRCC3
Clone: XRCC3 10F1/6
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: His-tagged human XRCC3
Positive Control:

HeLa nuclear extracts.

Cross Reactivity:

Human

Applications: Western
Growth Conditions:

DMEM + 5% FCS

Fusion Partner: Sp2/0Ag.14
Relevance: X-Ray Repair Cross Complementing 3 (XRCC3) is a RAD51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. XRCC3 is also a component of the homologous recombination pathway.
References:

Masson JY et al. 2001. Genes Dev. 15:3296-307. PMID: 11751635Read more
Masson JY et al. 2001. Proc. Natl. Acad. Sci. USA. 98:8440-6. PMID: 11459987 Read more
Tebbs RS et al. 1995. Proc. Natl. Acad. Sci. USA. 92:6354-8. PMID: 7603995Read more