| Antigen: | Mini Chromosome Maintenance protein-5 (MCM5) |
| Clone: | A2.10A12.A2.B11.A10 |
| Subclass | IgG |
| Species Raised In: | Mouse |
| Cross Reactivity: | Human |
| Applications: | Immunofluorescence, Western |
| Growth Conditions: | DMEM + 5%FCS |
| Synonyms: | Also known as: 352.10A12 |
| Relevance: | MCM5 (Mini Chromosome Maintainance protein-5) is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. MCM5 is a member of the MCM family of chromatin-binding proteins, which have DNA dependent ATPase motifs in their central domain. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may have a role in cell cycle regulation. MCM proteins 2-7 form a family of DNA helicases implicated at the initiation step of DNA synthesis. It has been reported that immunocytochemical assessment of MCM5 expression may be used as a diagnostic tool for cervical cancer and urothelial neoplasia. MCM5 expression may also be applicable in the detection of a number of other cancers including bladder, lung and oesophageal. |
© Cancer Research Technology 2012