Anti ASPP1 ASPP1 Polyclonal Profile
| Antigen: | ASPP1 |
| Clone: | ASPP1 |
| Subclass | IgG |
| Species Raised In: | Sheep |
| Immunogen: | Amino acids from human ASPP1 357-532 |
| Epitope: | Bacterially expressed protein |
| Cross Reactivity: | Human |
| Applications: | Immunofluorescence, Immunoprecipitation, Western |
| Synonyms: | Apoptosis Stimulating Protein of p53 |
| Relevance: | Stimulating protein of p53 (ASPP) contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. There are three known types of ASPP: ASPP1, ASPP2 and iASPP1. iASPP1 inhibits the proaptotic functions of ASPP1 and p53. |
| References: | Thornton et al., 2006. Oncogene 25:3104-12. PMID 16474851 Read more |
