Anti BCL11A Clone BCL11A Profile
| Antigen: | BCL11A (human) |
| Clone: | BCL11A |
| Subclass | IgG1 |
| Species Raised In: | Mouse |
| Immunogen: | C-terminus of extra long isoform of BCL11A, BCL11AXL (aa 637-835) |
| Epitope: | C-terminal epitope not defined further than original immunogen |
| Positive Control: | Tonsil |
| Cross Reactivity: | Human |
| Applications: | Immunohistochemistry, Immunoprecipitation, Western |
| Growth Conditions: | RPMI 1640 +10% FCS containing pen/strep, 1% ultroserG (supplier: PALL)+ and HAT |
| Fusion Partner: | NS-1 |
| Synonyms: | B cell CLL/lymphoma 11A extra long isoform (BCL11AXL), COUP TF interacting protein 1 (CTIP1), Ecotropic viral integration site 9 protein homolog (EVI9), Zinc finger protein 856 (ZNF856), HBFQTL5, FLJ10173, FLJ34997, KIAA1809, LOC53335 |
| Relevance: | BCL11A is a Krüppel zinc-finger transcription factor that was identified originally from a chromosome translocation in aggressive B-cell chronic lymphocytic leukaemia. The gene may function as both an oncogene and a tumour suppressor. Alternative splicing generates multiple isoforms, the BCL11AXL being the largest and most abundant transcript. The protein is differentially expressed during B-cell development and is strongly expressed in plasmacytoid dendritic cells. The BCL11A/123 antibody specifically recognises the extra long form of the protein and not the long or short forms of BCL11A. The BCL11A/123 antibody is not cross reactive with the long form of the BCL11B protein that shares significant sequence identity with the immunogen. |
| References: | Pulford et al., 2006. Leukemia. 20:1439-41. PMID: 16710303 Read more
|
| Notes: | Predicted to be 91KDa. |
