Anti HIF1A Clone ESEE122 Profile

Antigen: Hypoxia-Inducible Factor 1, Alpha Subunit (HIF1A)
Clone: ESEE122
Subclass IgG1
Species Raised In:

Balb/c

Immunogen: GST-human HIF-1A amino acids 329-530 fusion protein
Positive Control:

Hypoxic cell pellets.

Applications: ELISA, Frozen, Immunohistochemistry, Paraffin embedded
Growth Conditions:

RPMI + 10% FCS + HAT

Fusion Partner: NS-1
Synonyms: ARNT-interacting protein, Member of PAS protein 1, Basic-helix-loop-helix-PAS protein MOP1, PAS domain-containing protein 8, Class E basic helix-loop-helix protein 78, BHLHE78, MOP1, PASD8
Relevance: Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
References:

Beasley et al. 2002. Cancer Res. 62:2493-7. PMID: 11980639 Read more
Giatromanolaki et al. 2003. J. Pathol. 200:222-8. PMID: 12754744 Read more
Hui et al. 2002. Clin Cancer Res. 8:2595-604. PMID: 12171890 Read more
Talks et al. 2000. Am J Pathol. 1572:411-21. PMID: 10934146 Read more
Wiesener et al. 1998. Blood. 92:2260-8. PMID: 9746763Read more