| Antigen: | p53. large T-associated form of p53. |
| Clone: | PAb 1103 |
| Subclass | IgM |
| Species Raised In: | Balb/c |
| Immunogen: | A slice of gel containing p53 homogenised in PBS. The p53 was extracted from the human SV40-transformed fibroblast cell line SV8 |
| Positive Control: | MDA-MB-231 cell line |
| Cross Reactivity: | Human |
| Applications: | Immunoprecipitation |
| Growth Conditions: | DMEM + 5% FCS |
| Relevance: | p53 is a stress-regulated transcription factor that regulates cell cycle arrest and was first identified as an SV40 large T antigen-binding protein. Mutation of p53 is the most common genetic change so far identified in a number of major carcinomas. Pab 1103 is useful as research reagent to investigate structural similarity between large T and p53. |
| References: | Leppard K & Crawford L. 1983. EMBO J. 2:1457-64. PMID: 11892796Read more |
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