| Antigen: | RACO-1 |
| Clone: | 5H10 |
| Subclass | IgG1 |
| Species Raised In: | CD-1 Mouse |
| Immunogen: | Single C-terminal immunogenic peptide |
| Epitope: | Peptide corresponding to RACO-1 (aa174-189) |
| Cross Reactivity: | Human, Mouse, Rat |
| Applications: | ELISA, Immunoprecipitation, Western |
| Growth Conditions: | E4 + 5% FCS |
| Fusion Partner: | Sp-2 |
| Synonyms: | PDJ1B |
| Relevance: | RING-domain-containing protein (RACO-1) is a c-Jun co-activator that is regulated by the MEK signalling pathway. RACO-1 is a molecular link between growth factor signalling and AP-1. RACO-1 depletion reduces cellular proliferation and decreases expression of several growth-associated AP-1 target genes such as cdc2, cyclin D1 and hb-egf. |
| References: | Davies C et al. 2010. Nat Cell Biol. 12:963-72. PMID:20852630 Read more |
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