Anti CD70 Clone TAN 1-7 Profile

Antigen: CD70
Clone: TAN 1-7
Subclass IgG2a
Species Raised In:

Rat

Immunogen: Recombinant mouse CD70 (extracellular domain, aa residues 41-195)
Positive Control:

Activated dendritic cells.

Cross Reactivity:

Unknown

Applications: ELISA, FACS, Immunofluorescence
Growth Conditions:

RPMI + 10%FCS+ Penicillin-Streptomycin

Fusion Partner: NSO
Synonyms: CD27LG, TNFSF7
Relevance: CD70 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. This antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.
References:

Rowley et al. 2004. J Immunol. 172:6039-46. PMID 15128787 Read more
Taraban et al. 2008. J Immunol. 180:4615-20. PMID 18354184 Read more

Notes:

Suggested Dilutions: 1-10mg/ml