JIM3 Myeloma Cell Line

Relevance: In vitro study and comparison of genetic instability in myeloma tumour lines (homoplastic with JIM1); in vitro study of effects of DNA repair deficiency in myeloma tumour lines.
Description:

JIM3 myeloma tumour line demonstrating typical plasma cell phenotype (CD38, PCA-1 8A, CD24 positive), deficient in DNA repair.

Model Type: Tumour Line/ Panel
Species/Origin:

Human; derived from plasma myeloma cells derived from pleural fluid of advanced multiple myeloma patient, homoplastic with JIM1.

Phenotype Keywords:
Disease Keywords:
Recommended Growth Conditions:

JIM3 cell line can be grown in Dexter culture medium, consisting of Fischer’s medium with 20% FCS, penicillin (100U/ml), streptomycin (100mg/ml), fungizone (0.0125mg/ml), hydrocortisone sodium succinate (10-7 M).

References:

Hamilton et al. 1991. Leukemia. 5:768-71. PMID: 1943229Read more
Velangi et al. 2004. Carcinogenesis. 25:1795-803. PMID: 15142887Read more
Leone et al., 2008 Clin Cancer Res 14; 6033-41.Read more
Notes:

For more multiple myeloma tumour lines, see also JIM1 cell line