Inv-a2b1 Mouse

Gene/Protein Targets

a2 integrin, b1 integrin

Relevance: Disease model for psoriasis; in vivo study of human a2 and b1 integrin transgene expression in skin.
Model Type: Conditional, Transgenic Models
Genetic Background: CBA/C57BL/6
Zygosity: Heterozygous
Phenotype Keywords: Skin abnormalities
Disease Keywords: Psoriasis
Production Details:

Involucrin-integrin transgene expression constructs were injected into fertilised oocytes from F1 hybrid CBA/C57BL/6 mice. Transgene-positive mice were back-crossed to generate individual founder lines. The a2 transgene founder line was mated to the b1 integrin founder line to generate mice expressing both a2 and b1 integrin transgenes.

References:

Carroll et al, 1995. Cell. 83:957-65. PMID: 8521519Read more

Notes:

The Inv-a2b1 mouse presents a phenotype very similar to human psoriasis, and is an ideal tool for study of the disease in vivo. Inv-a2b1 mice demonstrate three key features of human psoriasis; abnormal keratinocyte differentiation, epidermal hyperproliferation, and inflammatory skin lesions. The mouse has conditional expression of integrins under involucrin promoter giving tissue-specific suprabasal epidermal expression.

For more psoriasis disease models, see also Inv-a3b1 mouse; Inv-a5b1 mouse; InvEE mouse.