Inv-IFNg mouse

Gene/Protein Targets

Interferon-g (IFNg)

Relevance: Disease model for systemic lupus erythematosus; in vivo study of IFNg expression in skin.
Model Type: Conditional, Transgenic Models
Zygosity: Heterozygous
Phenotype Keywords: Immune / lymphatic abnormalities, Skin abnormalities
Disease Keywords: Autoimmune disease, Systemic Lupus Erythematosus
Production Details:

An involucrin-interferon transgene expression construct was injected into fertilised oocytes from F1 hybrid CBA/C57BL/10 mice. Transgene-positive mice were mated to C57BL/10 mice to generate founder lines.

References:

Carroll et al. 1997. Journal of Investigative Dermatology. 108:412-22. PMID: 9077468Read more
Seery et al. 1997. Journal of Experimental Medicine. 186:1451-9. PMID: 9348302Read more
Notes:

The Inv-IFNg mouse presents a phenotype analogous to systemic lupus erythematosus, and is an ideal tool for study of the disease in vivo.

Inv-IFNg mice demonstrate key features of the lupus pathology:

Skin abnormalities;

- retarded hair growth, hypopigmentation of hair

- extreme age-related erythema (reddening of skin)

- flaky and pustular skin lesions, particularly around joints and appendages

Developmental abnormalities;

- growth retardation

- hunched appearance, odd gait

- enlarged spleens, shrunken thymus

Immune abnormalities;

- contact hypersensitivity

- autoantibody production, nephritis

For more autoimmune disease models, see also Inv-a5b1 mouse; InvEE mouse.