K14deltaNLef1 mouse

Gene/Protein Targets

Lef1 N-terminal mutant (constituitive transcriptional activity)

Relevance: In vivo study of Lef1 activity in skin; model for hair growth & follicle formation; disease model for skin tumour formation (sebaceous adenoma, sebeoma, squamous papilloma).
Model Type: Transgenic Models
Genetic Background: CBA x C57BL/6
Zygosity: Heterozygous
Phenotype Keywords: Skin abnormalities, Tumourigenesis
Disease Keywords:
Production Details:

A deltaNLef1 transgene vector, containing an N-terminally deleted mouse Lef1 cDNA under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.

References:

Niemann et al, 2002. Development. 129:95-109. PMID: 11782404Read more